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    Zanaflex (Tizanidine)Tizanidine (trade names include Zanaflex; Sirdalud; Ternelin; Tizan; Tizanidin Teva; Tizanidine Arrow; Tizanor; Tizpa) is a short-acting muscle relaxer from centrally acting muscle relaxants pharmacological group. This medicine is used for the treatment of muscle spasms, cramping, tightness of muscles caused by some diseases and medical conditions, such as spasticity, spastic diplegia, multiple sclerosis, amyotrophic lateral sclerosis (ALS), back pain, spinal cord injury, other injuries to the spine or CNS. It is also indicated to treat migraine headaches, some symptoms of fibromyalgia, as an anticonvulsant, as a sleep aid medication. Tizanidine HCl works by blocking nerve impulses (pain sensations) that are sent to your brain.

    Pharmacological and medical categories:

  • Alpha2-adrenergic agonists
  • Analgesics
  • Anti migraine medications
  • Anticonvulsants
  • Antispasmodics
  • Centrally acting skeletal muscle relaxants
  • Muscle relaxants
  • Pain relief drugs
  • Sleep aid pills

    The Anatomical Therapeutic Chemical (ATC) classification system codes:

  • M - Musculo-skeletal system
  • M03 - Muscle relaxants
  • M03B - Muscle relaxants, centrally acting agents
  • M03BX - Other centrally acting agents
  • M03BX02 - Tizanidine

    The International Statistical Classification of Diseases and Related Health Problems (ICD-10, World Health Organization) codes:

  • Amyotrophic lateral sclerosis - G12.21
  • Multiple sclerosis - G35
  • Epilepsy and recurrent seizures - G40
  • Migraine - G43
  • Sleep disorders - G47
  • Infantile cerebral palsy - G80
  • Spastic diplegic cerebral palsy - G80.1
  • Hemiplegia - G81
  • Paraplegia and tetraplegia - G82
  • Other diseases of spinal cord - G95
  • Dorsalgia - M54
  • Fibromyalgia - M79.7
  • Abnormal involuntary movements - R25
  • Injury of nerves and spinal cord at thorax level - S24

    Pregnancy categories:

  • C - Australia
  • C - United States (Risk cannot be ruled out)

    Salts and other forms used as active pharmaceutical ingredients (API):

  • Tizanidine Base
  • Tizanidine Hydrochloride

    Synonyms, international and chemical names:

  • 2,1,3-Benzothiadiazole, 5-chloro-4-(2-imidazolin-2-ylamino)-
  • 5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole
  • Tisanidine
  • Titsanidiini
  • Tizanidin
  • Tizanidina
  • Tizanidine HCL
  • Tizanidinhydrochlorid
  • Tinazidini Hydrochloridum
  • Tizanidinum
  • Tizanidyna

    Brands, generics, trade names in various countries:

  • Apo-Tizanidine - Apotex
  • Flexitine - Behrens Laboratorio
  • Miorelax - Bioquifar Pharmaceutica
  • Movax - Sami Pharmaceuticals
  • Musant - Niche Generics
  • Musidin - Martin Dow Pharmaceuticals
  • Mylan-Tizanidine - Mylan
  • Myores - Meprofarm
  • Myos-Nor - Best Laboratorios
  • Phardex - Pharos Chemie
  • Sirdalud - Novartis
  • Sirdalud Retard - Novartis
  • Sirdalud-MR - Novartis; Dr. Reddy's Laboratories; Euro Registratie; Medcor Pharmaceuticals
  • Ternelax - Wander; Zuellig Pharma
  • Ternelin - Novartis; Sandoz
  • Tilax - Riyadh Pharma
  • Tinize - Genome Pharmaceuticals
  • Tizacom - Combiphar
  • Tizafen - Akros Pharma
  • Tizan - Sun Pharmaceutical Industries
  • Tizanidin - Actavis; Alternova; Orion Pharma; Teva
  • Tizanidina - Davur Laboratorios; Teva
  • Tizanidine - Actavis; Alphapharm; Eon Labs; Generics UK; Mylan; Sandoz; Teva
  • Tizanor - Orion Pharma
  • Tizpa - Blue Cross Laboratories; Gold Cross; S.J. & G. Fazul Ellahie
  • Zanaflex - Acorda Therapeutics

    Pharmaceutical active ingredients used in medicine in combinations with tizanidine:

  • Aceclofenac
  • Acetaminophen
  • Ciprofloxacin
  • Diclofenac
  • Ibuprofen
  • Mefenamic Acid
  • Nimesulide
  • Serrapeptase
  • Valdecoxib

    Some other medications in the same pharmacological classes:

  • Anabloc (Fenyramidol)
  • Benemid (Probenecid)
  • Buscopan (Butylscopolamine)
  • Colospa (Mebeverine)
  • Decontractil (Mephenesin)
  • Dulcolax (Bisacodyl)
  • Flexeril (Cyclobenzaprine)
  • Imigran (Sumatriptan)
  • Imitrex (Sumatriptan)
  • Imuran (Azathioprine)
  • Lioresal (Baclofen)
  • Lyseen (Pridinol)
  • Mestinon (Pyridostigmine)
  • MuscoRil (Thiocolchicoside)
  • Mydeton (Tolperisone)
  • Myolastan (Tetrazepam)
  • Myonal (Eperisone)
  • Nimotop (Nimodipine)
  • Parafon (Chlorzoxazone)
  • Pletal (Cilostazol)
  • Ponstel (Mefenamic Acid)
  • Probalan (Probenecid)
  • Relafen (Nabumetone)
  • Requip (Ropinirole)
  • Robaxin (Methocarbamol)
  • Savella (Milnacipran)
  • Skelaxin (Metaxalone)
  • Tegretol (Carbamazepine)
  • Voveran (Diclofenac Sodium)
  • Urispas (Flavoxate)

    Here is a list of popular medications containing tizanidine as a main component of tizanidine drugs, their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:

    Trade name of the drug Pharmaceutical forms and doses Companies
  • Tablets; Oral; Tizanidine Hydrochloride 1 mg
  • Tablets; Oral; Tizanidine Hydrochloride 2 mg
  • Tablets; Oral; Tizanidine Hydrochloride 4 mg
  • Tablets; Oral; Tizanidine Hydrochloride 6 mg
  • Novartis
  • DKSH
  • Dr. Reddy's Laboratories
  • Eurim-Pharm
  • Laus Farma
  • Paranova Danmark
  • San Giorgio Pharma
  • Sandoz
  • Sanofi-Aventis
  • Zuellig Pharma
  • Ternelin
  • Granules; Oral; Tizanidine Hydrochloride 2 mg / g
  • Tablets; Oral; Tizanidine Hydrochloride 1 mg
  • Tablets; Oral; Tizanidine Hydrochloride 2 mg
  • Tablets; Oral; Tizanidine Hydrochloride 4 mg
  • Novartis
  • Sandoz
  • Tizan
  • Tablets; Oral; Tizanidine 2 mg
  • Tablets; Oral; Tizanidine 4 mg
  • Sun Pharmaceutical Industries
  • Pharmaland
  • Sin Phyu Kyun Company
  • Tizanidin-Teva
  • Tablets; Oral; Tizanidine Hydrochloride 2 mg
  • Tablets; Oral; Tizanidine Hydrochloride 4 mg
  • Tablets; Oral; Tizanidine Hydrochloride 6 mg
  • Teva
  • Tizanor
  • Tablets; Oral; Tizanidine Hydrochloride 2 mg
  • Tablets; Oral; Tizanidine Hydrochloride 4 mg
  • Orion Pharma
  • Zanaflex
  • Capsules; Oral; Tizanidine Hydrochloride 2 mg
  • Capsules; Oral; Tizanidine Hydrochloride 4 mg
  • Capsules; Oral; Tizanidine Hydrochloride 6 mg
  • Tablets; Oral; Tizanidine Hydrochloride 2 mg
  • Tablets; Oral; Tizanidine Hydrochloride 4 mg
  • Acorda Therapeutics
  • Cephalon
  • Elan Pharmaceuticals
  • Paladin Laboratories
  • Shire
  • Squire Pharmaceuticals
  • Zeneus Pharma

  • References:

  • PubChem database with main scientific information about active pharmaceutical ingredients : https://pubchem.ncbi.nlm.nih.gov/
  • PubMed database on US National Library of Medicine, National Institutes of Health: https://www.ncbi.nlm.nih.gov/pubmed/
  • DrugBank database containing information on drugs and drug targets: https://www.drugbank.ca/
  • MedlinePlus - an online information service produced by the United States National Library of Medicine: https://medlineplus.gov/
  • WebMD - an online publisher of news and information pertaining to human health and well-being: https://www.webmd.com/
  • Medscape - a website providing access to medical information for physicians and health professionals: https://www.medscape.com/
  • DailyMed drug labels resource from U.S. National Library of Medicine: https://dailymed.nlm.nih.gov/dailymed/spl-resources-all-drug-labels.cfm
  • Mayo Clinic - a nonprofit academic medical center focused on integrated clinical practice, education, and research: https://www.mayoclinic.org/
  • Drugs@FDA: U.S. Food and Drug Administration approved drug products database: https://www.accessdata.fda.gov/scripts/cder/daf/
  • Drug Product Database online query from Health Canada: https://health-products.canada.ca/dpd-bdpp/index-eng.jsp
  • European Medicines Agency (EMA) website with "Search for medicines" tool for European Union countries: https://www.ema.europa.eu/en
  • UK drug database from electronic Medicines Compendium (eMC): https://www.medicines.org.uk/emc
  • Australian medicine finder from NPS MedicineWise: https://www.nps.org.au/medicine-finder
  • Agencia Espanola de Medicamentos y Productos Sanitarios - AEMPS: https://www.aemps.gob.es/
  • Pharma and medical DB in EU on CBG-MEB: https://www.cbg-meb.nl/
  • Huge database for drug search especially for european and Latin America region: https://www.vademecum.es/equivalencia
  • MyHealthbox - multilanguage search engine for official information on medicines and healthcare products: https://myhealthbox.eu/en/
  • Pharmaceutical and other healthcare databases in some countries, primarily across Asia Pacific: https://www.mims.com/
  • MIMS drug index in China: http://www.mims.com.cn/china/drug/index/
  • IndiaMart - Various exploring tools, including for medical and pharmaceutical products in India: https://dir.indiamart.com/
  • A to Z brands and generics with their comparative prices on MedGuideIndia: http://www.medguideindia.com/show_generics.php
  • Generic drugs with their brand names on Medindia: https://www.medindia.net/drug-price/index.asp
  • Online Drug Information System, primarily for India and Pakistan: http://www.druginfosys.com/
  • Medizzine - hispanic portal for medicines: http://www.medizzine.com/pacientes/medicamentos/index.php
  • English version of Medizzine - health & medicines portal: http://www.medizzine.com/en/patients/drugs/index.php
  • Search tools for medications on Japanese Orange Book: http://www.jp-orangebook.gr.jp/cgi-bin/search/search_e.cgi
  • South Korean PharmaLink gateway: http://www.pharmalink.kr/
  • Medicines brand and generic index for Africa region: https://daktariafrica.com/medicine/raw/index/
  • APIs database on Galinos: https://www.galinos.gr/web/drugs/main/substances
  • RLSNet index for drugs, nutritions and supplements in Russia, Eastern Europe and Middle Asia regions: https://www.rlsnet.ru/tn_alf.htm
  • Taiwan Food and Drug Administration: https://www.fda.gov.tw/TC/index.aspx
  • Online medicine information directory from MedEx: https://medex.com.bd/generics/
  • The Anatomical Therapeutic Chemical ATC/DDD Index 2019: https://www.whocc.no/atc_ddd_index/
  • International Statistical Classification of Diseases and Related Health Problems 10th Revision, WHO: https://www.icd10data.com/

    Updated: September, 2019

    Disclaimer: Please note, this website is not an online pharmacy, drugstore and related online pharma shop. It does not sell, supply or advertise any prescription and OTC drugs, medications, other goods and services. All reviews, links, lists, databases, texts, and other content on the website are provided free and only for informational and educational purposes. Medical content on this website, including drug names, indications, contraindication, side effects, categories, classifications, forms, doses, prices, other health and pharmaceutical information are taken only from trusted and authoritative professional sources (see "References"), reviewed and prepared by our licensed experts, content inspectors and editors.
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